Best of heart failure

7 is that ischemia accounts for more than 50% of cases [ 8 ]. In s HF cases had antecedent hypertension. An increased ratio of HDL cholesterol is associated with increased risk of develo study, 49%of the subjects who had underlying sleep apnea hadH noncompliance with HF medications, poor diet including high and fatty foods, c an contribute to worsening of HF . Assessment of the Heart Failure Patient A number of criteria should be taken into consideration when with advanced HF including the number of previous admission tension, intolerance to angiotensin converting enzyme (ACE)/ blockers (ARB), and beta blockers, widening of the QRS co ness to biventricular pacing, worsening exertional tolerance, w tion, elevated HF biomarkers, and psychosocial factors. Common symptoms in HF patients include fatigue and d Dyspnea can range from shortness of breath with mild exerti paroxysmal nocturnal dyspnea. As such, patients report im ening in dyspnea marked by inability to walk a few block stairs as they move through the different classes of NY symptoms include lower extremity swelling, abdominal appetite, early satiety, drowsiness, and overall lack of energ ing and peripheral edema are common manifestations of flu more prevalent in the advanced HF population. Some o advanced HF include the following: need for inotropic sup medications, persistent hyponatremia, NYHA III–IV symp hospitalizations, and worsening renal function [ 6 , 11 ]. Sin disease, many patients adapt to their symptoms by decreasin duration of their activities of daily living. Because this occur of time, it is possible for HF patients to have advanced H significant symptoms or signs of HF. Physical exam findings associated with advanced HF inclu ular veno us distention, rales on auscultation, hypotension, a The presence of jugular venous pressure (JVP) in HF patients ing. Data suggest that JVP is a reasonably good assessment o pressures in chronic HF patients. Sensitivity and specificity fo predict a pulmonary capillary wedge pressure >18 approac 80%, respectively [ 12 ]. JVP is a good prognostic marker as w analysis, elevated JVP was associated with an increased risk fo HF and increased risk of overall mortality. Presence of an S3 associated with worse outcomes [ 13 ]. Although the presence of is suggestive of severe HF and volume overload, the absence o 1 Management of Advanced Heart Failure: An Overview Palliative Care Despite significant advancement in medical therapy to improve survival and quality of life, advanced HF still carries a poor prognosis. These patients usually are older and have underlying comorbidities, poor quality of life, and common complaints like dyspnea, depression, pain, and fatigue. Since many healthcare providers are seeing advanced HF patients, these patients often have a sense of uncertainty about prognosis and feel left out due to lack of communication. End of life transition and the whole process dealing with it is an unfamiliar territory for most. Furthermore, there is significant psychosocial burden on the family when a loved one is inflicted with HF. Palliative care strives to provide an improved quality of life and focuses on symptoms rather than therapy to prolong life. It takes into account the patient and family as a whole and looks to alleviate suffering. Palliative care is underutilized in this patient population [49]. References 1. Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646–59. https://doi. org/10.1161/CIRCRESHAHA.113.300268. 2. Massie BM, Shah NB. Evolving trends in the epidemiologic factors of heart failure: rationale for preventive strategies and comprehensive disease management. Am Heart J. 1997;133:703–12. 3. Norton C, Georgiopoulou VV, Kalogeropoulos AP, et al. Epidemiology and cost of advanced heart failure. Prog Cardiovas Dis. 2011;54(2): 78–85. 4. Friedrich EB, Bohm M. Management of end stage heart failure. Heart. 2007;93(5):626–31. https://doi.org/10.1136/hrt.2006.098814. 5. Abouezzeddine OF, Redfield MM. Who has advanced heart failure? Definition and epidemiology. Congest Heart Fail. 2011;17(4):160–8. https://doi.org/10.1111/j.1751-7133.2011.00246.x. 6. Chaudhry SP, Stewart GC. Advanced heart failure: prevalence, natural history, and prognosis. Heart Fail Clin. 2016;12(3):323–30. 7. Ali A, Aronow WS, Fleg JL. Higher New York Heart Association classes and increased mortality and hospitalization in heart failure patients with preserved left ventricular function. Am Heart J. 2006;151(2): 444–50. 8. Remme WJ. Overview of the relationship between ischemia and congestive heart failure. Clin Cardiol. 2000;23:IV-4–8. https://doi. org/10.1002/clc.4960230703. 9. Bui AL, Horwich TB, Fonarow GC. Epidemiology and risk profile of heart failure. Nat Rev Cardiol. 2011;8(1):30–41. 10. Sogol J, Javaheri S, Javaheri A. Sleep Apnea, heart failure, and pulmonary hypertension. Curr Heart Fail Rep. 2013;10(4):315–20. 11. Leiro MGC, Martin MJP. Management of advanced or refractory heart failure. Rev Esp Cardiol. 2004;57:869–83. Vol. 57, num.09. https://doi. org/10.1016/S1885-5857(06)60652-X. 12. Rame JE, Dries DL, Drazner MH. The prognostic value of the physical examination in patients with chronic heart failure. CHF. 2003;9(3): 170–5. 13. Drazner MH, Rame JE, Stevenson LW, et al. Prognostic importance of elevated jugular venous pressure and a third heart sounds in patients with heart failure. N Engl J Med. 2001;345(8): 574–81. https://doi. org/10.1056/NEJMoa010641. 14. Nohria A, Lewis E, Stevenson LW. Medical management of advanced heart failure. JAMA. 2002;287(5):628–40. https://doi.org/10.1001/ jama.287.5.628. 15. Stevenson LW. Hemodynamic goals are r levant. Circulation. 2006;113:1020–33. 16. Potluri S, Ventura HO, Mulumudi M. Cardiac troponin levels in heart failure. Cardiol Rev. 2004;12(1):21–5. 17. Shah BN, Greaves K. The cardiorenal syndrome. A review. Int J Nephrol. 2011;2011:920195. https://doi.org/10.4061/2011/920195. 18. Pokhrel N, Maharjan N, Dhakal B, et al. Cardiorenal syndrome: A literature review. Exp Clin Cardiol. 2008;13(4):165–70. 19. Makani H, Bangalone S, Romero J, et al. Peripheral edema associated with calcium channel bl ckers: incidence and withdrawal ratea metaanalysis of randomized trials. J Hypertens. 2011;29(7):1270–80. https://doi.org/10.1097/HJH.0b013e3283472643. 20. Packer M, Carson P, Elkayam U, et al. Effect of amlodipine on the survival of patients with severe chronic heart failure due to nonischemic cardiomyopathy. JACC Heart Fail. 2013;1(4):308–14. 21. Colucci WS, Fifer MA, Lorell BH, et al. Calcium channel blockers in congestive heart failure: theoretic considerations and clinical experience. Am J Med. 1985;78(2B):9–17. 22. Gibbs CR, Jackson G, GYH L. Non-drug management. BMJ. 2000; 320(7231):366–9. 23. Yusuf S, Pitt B, Davis CE, et al. Effect of enalapril on urvival in patients with reduced left ventricular ejection fractions and congestive h art failure. N Engl J Med. 1991;325(5):293–302. 24. The Consensus Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. N Engl J Med. 1987;316:1429– 35. 25. Young JB, Dunlap ME, Pfeffer MA, et al. Mortality and morbidity reductio with Candesartan in pati nts with chr nic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials. Circulation. 2004;110(17):2618– 26. 26. Lakhdar R, Al-Mallah MH, Lanfear DE. Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combi ation of angiotensin-converting enzyme inhibitor and ang otensin receptor blocker in patients with left ventricular dysfunction: a systematic review and meta-analysis of randomized controlled trials. J Card Fail. 2008;14(3):181–8. 27. Mcmurray JJV, Packer M, Desai AS, et al. Angiotensin-Neprilysin inhibition versus enalapril i heart failure. N Engl J Med. 2014;371:993–1004. http ://doi. rg/10.1056/NEJMoa1409077. 28. Goldstein S, Hjalmarson A. The mortality effect of metoprolol CR/ XL in patients with heart failure: results of the MERIT-HF trial. Clin Cardiol. 1999;22(Suppl 5):V30–5. 29. CIBIS-II Investigators. The Cardiac Insufficiency Bisoprolol Study (CIBIS-II): a randomized trial. Lancet. 1999;353(9146):9–13. 30. Packer M, Bristow MR, Cohn JN, et al. The effect of carvedilol on morbidity nd mortality in patients with chronic heart failure. N Engl J Med. 1996;334:1349–55. 31. Packer M, Coats AJS, Fowler MB, et al. Effect of Carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001;344:1651–8. 32. Barrese V, Taglialatela M. New advances in beta-blocker therapy in heart failure. Front Physiol. 2013;4:323. https://doi.org/10.3389/ fphys.2013.00323. 33. Gheorghiade M, Colucci WS, Swedberg K. B-Blockers in chronic heart failure. Circulation. 2003;107:1570–5. 34. Taylor AL, Ziesche S, Yancy C, et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004;351:2049–57. https://doi.org/10.1056/ NEJMoa042934. 35. Cole RT, Kalogeropoulos AP, Georgiopoulou VV, et al. Hydralazine and isosorbide dinitrate in heart failure: historical perspective, mechanisms, and future directions. Circulation. 2011;123(21):2414– 22.

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